Process for making tablet using radiofrequency and lossy coated particles

{
  "publication_number": "US10493026B2",
  "country": "US",
  "kind": "B2",
  "title": "Process for making tablet using radiofrequency and lossy coated particles",
  "abstract": "In one aspect the present invention features a process for making a tablet comprising the step of applying radiofrequency energy to a powder blend comprising lossy coated particles and at least one pharmaceutically active agent to sinter said powder blend into a tablet, said lossy coated particles comprising a substrate having a Q value of greater than 100 that is at least partially coated with a lossy coating comprising Hydrogenated Starch Hydrolysate.",
  "claims": [
    "1. A process for making a tablet comprising the step of applying radiofrequency energy to a powder blend comprising lossy coated particles and at least one pharmaceutically active agent to sinter said powder blend into a tablet, said lossy coated particles comprising a substrate having a Q value of greater than 100 that is at least partially coated with a lossy coating; wherein said lossy coated particles comprise from about 1.5 to about 2.5%, by weight, of Hydrogenated Starch Hydrolysate and the hardness of the tablet is 1 kp or greater.",
    "2. A process of claim 1, wherein said substrate has a Q value of greater than 200.",
    "3. A process of claim 1, wherein said lossy coated particles have a Q value of greater than 100.",
    "4. A process of claim 1, wherein said powder blend has a Q value of greater than 100.",
    "5. A process of claim 1, wherein said powder blend comprises at least 20%, by weight, of said lossy coated particles.",
    "6. A process of claim 1, wherein said lossy coated particle comprises from about 0.1% A to about 3%, by weight, water.",
    "7. A process of claim 1, wherein said tablet disintegrates in the mouth when placed on the tongue in less than about 30 seconds.",
    "8. A process of claim 1, wherein said tablet disintegrates in the mouth when placed on the tongue in less than about 15 seconds.",
    "9. The process of claim 1, wherein said radiofrequency energy has a frequency of from about 13 MHz to about 40 MHz.",
    "10. A process of claim 1, wherein said tablets are formed within a tablet die.",
    "11. A process of claim 1, wherein said substrate comprises a starch, a sugar alcohol, or a sugar.",
    "12. A process of claim 1, wherein said substrate comprises maltitol or mannitol.",
    "13. A process of claim 1, wherein said substrate comprises said pharmaceutically active agent.",
    "14. A process of claim 1, wherein the friability of the tablet is less than about 5%.",
    "15. The process of claim 1 wherein said tablet disintegrates in the mouth when placed on the tongue in less than about 15 seconds.",
    "16. The process of claim 1 wherein said powder blend comprises lossy coated particles separate from said at least one pharmaceutically active agent.",
    "17. A sintered tablet comprising sintered lossy coated particles and at least one pharmaceutically active agent, wherein said lossy coated particles comprise a substrate that is at least partially coated with a lossy coating, wherein said lossy coated particles comprise from about 1.5 to about 2.5% by weight of Hydrogenated Starch Hydrolysate, said substrate has a Q value of greater than 100, said tablet having a hardness of 1 kp or greater and said tablet disintegrates in the mouth when placed on the tongue in less than about 15 seconds."
  ],
  "description_excerpt": "Pharmaceuticals intended for oral administration are typically provided in tablet form. Tablets can be swallowed whole, chewed in the mouth, or disintegrated in the oral cavity. Soft tablets that either are chewed or dissolve in the mouth are often employed in the administration of pharmaceuticals where it is impractical to provide a tablet for swallowing whole. With chewable tablets, the act of chewing helps to break up the tablet particles as the tablet disintegrates and may increase the rate of absorption by the digestive tract. Soft tablets are also advantageous where it is desirable to make a pharmaceutically active agent available topically in the mouth or throat for both local effects and/or systemic absorption. Soft tablets are also utilized to improve drug administration in pediatric and geriatric patients. Soft tablets designed to disintegrate in the mouth prior to swallowing are particularly useful for improving compliance of pediatric patients.\n\nGenerally, soft tablets are made by compaction of a blend of powdered ingredients and typically include a pharmaceutically active agent, flavoring, and/or binders. The powder blend is typically fed into the cavity of a die of a tablet press and a tablet is formed by applying pressure. Hardness of the resulting tablet is a direct function of the compaction pressure employed and the compatibility of the ingredients in the formulation. A softer tablet, having an easier bite-through, may be prepared by employing reduced compaction pressures.",
  "cpc": [
    "A61K 9/0056",
    "A61K 31/138",
    "A61K 31/167",
    "A61K 9/0007",
    "A61K 9/2018",
    "A61K 9/2059",
    "A61K 9/2081",
    "A61K 9/2095",
    "A61K 9/50",
    "A61K 9/5036"
  ],
  "ipc": [
    "A61K 31/167",
    "A61K 9/00",
    "A61K 9/20",
    "A61K 31/138",
    "A61K 9/50"
  ],
  "assignees": [
    "Johnson and Johnson Consumer Inc"
  ],
  "inventors": [
    "Gregory Koll",
    "Gerard McNally",
    "Christopher E. Szymczak"
  ],
  "filing_date": "2017-03-20",
  "publication_date": "2019-12-03",
  "grant_date": "2019-12-03",
  "priority_date": "2017-03-20",
  "application_number": "US-201715463609-A",
  "family_id": "61873900",
  "cited_by_count": 3,
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