Monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma

{
  "publication_number": "US2005287148A1",
  "country": "US",
  "kind": "A1",
  "title": "Monoclonal antibody 1A7 and use for the treatment of melanoma and small cell carcinoma",
  "abstract": "The present invention relates to monoclonal antibody 1A7. This is an anti-idiotype produced by immunizing with an antibody specific for ganglioside GD2, and identifying a hybridoma secreting antibody with immunogenic potential in a multi-step screening process. Also disclosed are polynucleotide and polypeptide derivatives based on 1A7, including single chain variable region molecules and fusion proteins, and various pharmaceutical compositions. When administered to an individual, the 1A7 antibody overcomes immune tolerance and induces an immune response against GD2, which comprises a combination of anti-GD2 antibody and GD2-specific T cells. The invention further provides methods for treating a disease associated with altered GD2 expression, particularly melanoma, neuroblastoma, glioma, soft tissue sarcoma, and small cell carcinoma. Patients who are in remission as a result of traditional modes of cancer therapy may be treat with a composition of this invention in hopes of reducing the risk of recurrence.",
  "claims": [
    "1. Monoclonal antibody 1A7. 2. An antibody producing cell deposited under ATCC Accession No. HB-11786, and the progeny thereof. 3. An antibody producing cell having all the identifying characteristics of a cell according to claim 2. 4. A purified antibody having identifying characteristics identical to antibody produced by a cell according to claim 2. 5. A polynucleotide comprising a sequence encoding a polypeptide with immunological activity of monoclonal antibody 1A7, wherein the polypeptide comprises at least 5 consecutive amino acids from a variable region of monoclonal antibody 1A7. 6. A polynucleotide according to claim 5, wherein the variable region is from a light chain. 7. A polynucleotide according to claim 5, wherein the variable region is from a heavy chain. 8. The polynucleotide of claim 5, wherein the 5 consecutive amino acids is contained in SEQ. ID NO:2. 9. The polynucleotide of claim 5, wherein the 5 consecutive amino acids is contained in SEQ. ID NO:4. 10. The polynucleotide of claim 5, wherein the encoding sequence is contained in SEQ. ID NO: 1. 11. The polynucleotide of claim 5, wherein the encoding sequence is contained in SEQ. ID NO:3. 12. An polynucleotide according to claim 5, wherein the polynucleotide encodes at least 5 consecutive amino acids of a complementarity determining region (CDR). 13 - 14. (canceled) 15. A polynucleotide according to claim 5, wherein the polynucleotide is a cloning vector. 16. A polynucleotide according to claim 5, wherein the polynucleotide is an expression vector. 17. The expression vector of claim 16, wherein the expression vector is vaccinia. 18. A host cell comprising a polynucleotide according to claim 5. 19 - 35. (canceled) 36. A pharmaceutical composition comprising the polynucleotide of claim and a pharmaceutically acceptable excipient. 37. (canceled) 38. A vaccine comprising monoclonal antibody 1A7 of claim 1 and a pharmaceutically acceptable excipient. 39. A vaccine comprising the polynucleotide of claim 5 and a pharmaceutically acceptable excipient. 40. (canceled) 41. The vaccine of claim 38, comprising an adjuvant. 42 - 61. (canceled)"
  ],
  "cpc": [
    "C07K 16/3084",
    "A61K 2039/505",
    "A61K 2039/53",
    "A61K 2039/55577",
    "A61K 39/00",
    "A61K 39/285",
    "A61K 39/395",
    "A61K 48/00",
    "A61P 37/04",
    "C07K 14/535",
    "C07K 14/55",
    "C07K 16/4241",
    "C07K 16/4266",
    "C07K 2317/24",
    "C07K 2317/56",
    "C07K 2317/622",
    "C07K 2319/00",
    "C07K 2319/30",
    "C12N 15/86",
    "C12N 2710/24143",
    "C12N 2799/023",
    "C12Q 1/68",
    "G01N 33/575",
    "G01N 33/577"
  ],
  "assignees": [
    "CHATTERJEE MALAYA",
    "FOON KENNETH A",
    "CHATTERJEE SUNIL K"
  ],
  "filing_date": "2005-03-23",
  "publication_date": "2005-12-29",
  "priority_date": "1995-01-17",
  "application_number": "US-8926605-A",
  "family_id": "23469193",
  "citations": [
    "US2003114398A1",
    "US4675287A",
    "US4693966A",
    "US4722840A",
    "US4737456A",
    "US4849509A",
    "US4904596A",
    "US4918164A",
    "US4965498A",
    "US5009995A",
    "US5053224A",
    "US5057540A",
    "US5091177A",
    "US5102663A",
    "US5134075A",
    "US5141742A",
    "US5208146A",
    "US5240833A",
    "US5242824A",
    "US5270202A",
    "US5305559A",
    "US5308614A",
    "US5529922A",
    "US5571900A",
    "US5612030A",
    "US5653977A",
    "US5935821A",
    "US5977316A",
    "US6509016B1"
  ]
}