Fexofenadine hydrochloride

{
  "id": "MLC-T-ONC-013574",
  "term": "Fexofenadine hydrochloride",
  "field": "Oncology and biomedicine",
  "definition": "The hydrochloride salt form of fexofenadine, a carboxylated metabolic derivative of terfenadine and third generation selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects. Fexofenadine competitively binds peripheral H1-receptors, thereby stabilizing an inactive conformation of the receptor. Consequently histamine binding and activity as a result of mast-cell degranulation followed by the release of multiple inflammatory mediators, such as interleukins, prostaglandin and leukotriene precursors, is blocked, thereby preventing the triggering of pro-inflammatory pathways.",
  "synonyms": [
    "fexofenadine HCl"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fexofenadine-hydrochloride/"
}