variant of unknown significance

{
  "id": "MLC-T-ONC-009171",
  "term": "variant of unknown significance",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A change in a gene’s DNA sequence that has an unknown effect on a person’s health. There is usually not enough information about a variant of unknown significance to know whether it increases a person’s risk of developing a disease, such as cancer. Also called unclassified variant, variant of uncertain significance, and VUS.",
    "A variation in a genetic sequence for which the association with disease risk is unclear. Also called unclassified variant, variant of uncertain significance, and VUS."
  ],
  "synonyms": [
    "unclassified variant",
    "variant of uncertain significance",
    "VUS"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "NCI Dictionary of Genetics Terms"
  ],
  "url": "https://mlchart.com/terminology/oncology/variant-of-unknown-significance/"
}