Complete genome sequence of the methanogen Methanobrevibacter ruminantium

{
  "publication_number": "US10314895B2",
  "country": "US",
  "kind": "B2",
  "title": "Complete genome sequence of the methanogen Methanobrevibacter ruminantium",
  "abstract": "The present invention includes the complete genome sequence for the methanogen, Methanobrevibacter ruminantium, including polynucleotides which encode M. ruminantium polypeptides or peptides, as well as polynucleotides from non-coding regions. Also included are the encoded M. ruminantium polypeptides and peptides, and antibodies directed to these peptides or polypeptides, in addition to expression vectors and host cells for producing these peptides, polypeptides, polynucleotides, and antibodies. The invention further includes methods and compositions for detecting, targeting, and inhibiting microbial cells, especially methanogen cells such as M. ruminantium cells, using one or more of the disclosed peptides, polypeptides, polynucleotides, antibodies, expression vectors, and host cells.",
  "claims": [
    "1. A vaccine composition comprising an adjuvant, and a polypeptide comprising the amino acid sequence of SEQ ID NO: 7041.",
    "2. The vaccine composition of claim 1, wherein the polypeptide comprises a conjugate or fusion molecule.",
    "3. The vaccine composition of claim 1, wherein the vaccine composition is an animal vaccine composition against a methanogen.",
    "4. The vaccine composition of claim 3, wherein the methanogen is Methanobrevibacter ruminantium.",
    "5. The vaccine composition of claim 3, wherein the animal is a ruminant.",
    "6. The vaccine composition of claim 5, wherein the ruminant is selected from the group consisting of cattle, sheep, goats, buffalo, moose, antelope, caribou, and deer.",
    "7. The vaccine composition of claim 1, wherein the vaccine composition is a ruminant vaccine composition for use in reducing methane emissions.",
    "8. A kit for reducing methanogen growth or methane production in a ruminant comprising the vaccine composition of claim 1.",
    "9. A method of vaccinating an animal against a methanogen, comprising the step of administering to said animal, the vaccine composition according to claim 1.",
    "10. The method of claim 9, wherein the methanogen is Methanobrevibacter ruminantium.",
    "11. The method of claim 9, wherein the animal is a ruminant.",
    "12. The method of claim 11, wherein the ruminant is selected from the group consisting of cattle, sheep, goats, buffalo, moose, antelope, caribou, and deer.",
    "13. A method of reducing methane emissions from a ruminant, comprising vaccinating the ruminant against a methanogen according to claim 9."
  ],
  "description_excerpt": "The present invention encompasses the complete genome sequence for the methanogen, Methanobrevibacter ruminantium. The invention encompasses polynucleotides which encode M. ruminantium polypeptides or peptides, as well as polynucleotides from non-coding and intergenic regions. Also encompassed are the encoded M. ruminantium polypeptides and peptides, and antibodies directed to these peptides or polypeptides. The invention also encompasses expression vectors and host cells for producing these peptides, polypeptides, polynucleotides, and antibodies. The invention further encompasses methods and compositions for detecting, targeting, and inhibiting microbial cells, especially methanogen cells such as M. ruminantium cells, using one or more of the disclosed peptides, polypeptides, polynucleotides, antibodies, expression vectors, and host cells.\n\nGlobal surface temperatures are predicted to increase between 1.1° C. to 6.4° C. during the twenty-first century primarily due to increased levels of greenhouse gases (GHGs) in the atmosphere (Solomon et al., 2007). Methane (CH 4) is a particularly potent GHG, having a global warming potential 21 times that of carbon dioxide (CO 2) (IPCC, 2007) and accounts for 16% of total global GHG emissions (Scheehle & Kruger, 2006). Methane from agriculture represents around 40% of the emissions produced by human-related activities, the single largest source of which is from enteric fermentation in livestock, mainly from ruminant animals (Steinfeld et al., 2006).",
  "cpc": [
    "A61K 39/0001",
    "A61K 2039/552",
    "C07K 14/195",
    "C07K 16/1267",
    "C12N 15/74",
    "G01N 2333/195",
    "Y02E 50/10",
    "Y02E 50/30",
    "Y02P 60/22"
  ],
  "ipc": [
    "A61K 39/00",
    "C07K 14/195",
    "C07K 16/12",
    "C12N 15/31",
    "C12N 15/74"
  ],
  "assignees": [
    "Pastoral Greenhouse Research Ltd"
  ],
  "inventors": [
    "Eric Heinz Altermann",
    "Graeme Trevor attwood",
    "Gregory Cook",
    "Debjit Dey",
    "Scott A Ferguson",
    "Petrus Hendricus Janssen",
    "William John Kelly",
    "Zhanhao Kong",
    "Suzanne Lambie",
    "Sinead Christine Leahy",
    "Dong Li",
    "Duncan McMillan",
    "Sharla McTavish",
    "Diana Pacheco",
    "Robert Starr Ronimus",
    "Carrie Sang",
    "Carl Yeoman"
  ],
  "filing_date": "2016-07-19",
  "publication_date": "2019-06-11",
  "grant_date": "2019-06-11",
  "priority_date": "2009-08-27",
  "application_number": "US-201615213596-A",
  "family_id": "43628216",
  "cited_by_count": 6,
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}