Factor VIII polymer conjugates

{
  "publication_number": "US11020458B2",
  "country": "US",
  "kind": "B2",
  "title": "Factor VIII polymer conjugates",
  "abstract": "The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.",
  "claims": [
    "1. A composition comprising: (a) a Factor VIII molecule; and (b) at least one water soluble polymer bound to said Factor VIII molecule, wherein said water soluble polymer is attached to the Factor VIII via an oxidized carbohydrate moiety; wherein said water soluble polymer is selected from the group consisting of polyethylene glycol (PEG), polysialic acid (PSA) and dextran; wherein said water soluble polymer is linear; wherein said water soluble polymer has a molecular weight of 2,000 to 150,000 Da; wherein the Factor VIII is a recombinant Factor VIII; wherein said molecule retains at least 50% of native FVIII activity; and said composition is substantially free from albumin."
  ],
  "description_excerpt": "This application is a continuation of U.S. application Ser. No. 15/213,802, filed on Jul. 19, 2016, (now abandoned), which is a continuation of U.S. application Ser. No. 14/736,870, filed on Jun. 11, 2015, (now abandoned), which is a continuation of U.S. application Ser. No. 13/756,856, filed Feb. 1, 2013, (now abandoned), which is a continuation of U.S. application Ser. No. 13/243,550, filed Sep. 23, 2011, (now abandoned), which is a continuation of U.S. application Ser. No. 13/010,627, filed Jan. 20, 2011 (now issued as U.S. Pat. No. 8,071,728), which is a divisional of U.S. application Ser. No. 12/684,536, filed Jan. 8, 2010 (now issued as U.S. Pat. No. 8,003,760), which is a divisional of U.S. application Ser. No. 12/184,567, filed Aug. 1, 2008 (now issued as U.S. Pat. No. 7,645,860), which is a continuation-in-part of U.S. application Ser. No. 11/729,625, filed on Mar. 29, 2007, (now issued as U.S. Pat. No. 7,683,158) which claims priority to U.S. Provisional Application Nos. 60/790,239 and 60/787,968, which were filed on Apr. 6, 2006 and Mar. 31, 2006, respectively, and U.S. application Ser. No. 13/010,627, filed Jan. 20, 2011, is a divisional of U.S. application Ser. No. 12/184,567, filed Aug. 1, 2008, (now issued as U.S. Pat. No. 7,645,860).\n\nThe present invention relates to a proteinaceous construct comprising coagulation factor VIII (FVIII) being bound to at least one water soluble polymer, including a poly(alkylene oxide) such as polyethylene glycol.",
  "cpc": [
    "A61K 38/37",
    "A61K 38/00",
    "A61K 38/18",
    "A61K 47/50",
    "A61K 47/60",
    "A61K 47/61",
    "A61P 7/00",
    "A61P 7/04",
    "C07K 14/745",
    "C07K 14/755"
  ],
  "ipc": [
    "A61K 38/37",
    "A61K 47/60",
    "A61K 47/61",
    "C07K 14/745"
  ],
  "assignees": [
    "Takeda Pharmaceutical Co Ltd"
  ],
  "inventors": [
    "Peter Turecek",
    "Juergen Siekmann"
  ],
  "filing_date": "2019-02-26",
  "publication_date": "2021-06-01",
  "grant_date": "2021-06-01",
  "priority_date": "2006-03-31",
  "application_number": "US-201916285394-A",
  "family_id": "41404469",
  "cited_by_count": 9,
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