Patent · US11243494B2 · B2 · US
Multiple laminar flow-based particle and cellular separation with laser steering
- (11) Publication number
- US11243494B2
- (21) Application number
- 16/239,297
- (22) Filing date
- 2019-01-03
- (30) Priority date
- 2002-07-31
- (43) Publication date
- 2022-02-08
- (45) Date of grant
- 2022-02-08
- (51) IPC
- A61L 2/08; B01D 21/01; B01D 21/26; B01L 3/00; B03C 1/00; B04B 13/00; G01N 21/64; G01N 27/447; G01N 33/487; G01N 33/50; G02B 21/32; G03H 1/00; G21K 1/00; G21K 5/08; H05H 3/04; G01N 15/02; G01N 33/49
- (52) CPC
- G03H Holographic processes or apparatus: 1/0005, 1/08, 1/2294, 2001/0077, 2001/085, 2225/32
- A61L Methods or apparatus for sterilising materials or objects in general; disinfection, sterilisation or deodorisation of air; chemical aspects of bandages, dressings, absorbent pads or surgical articles; materials for bandages, dressings, absorbent pads or surgical articles: 2/08, 2/10, 2103/05, 2103/09
- A61M Devices for introducing media into, or onto, the body; devices for transducing body media or for taking media from the body; devices for producing or ending sleep or stupor {}: 1/36, 1/3603, 1/3678, 1/3693, 1/38, 2206/11
- B01D Separation: 21/0009, 21/01, 21/262, 2221/10
- B01L Chemical or physical laboratory apparatus for general use: 2200/0652, 2200/0668, 2300/0864, 2400/0454, 3/502761, 3/502776
- B03C Magnetic or electrostatic separation of solid materials from solid materials or fluids; separation by high-voltage electric fields: 1/00, 1/002, 1/28, 1/288, 2201/02, 2201/18, 2201/26, 5/005
- B04B Centrifuges: 13/00
- G01N Investigating or analysing materials by determining their chemical or physical properties: 15/0205, 15/0227, 15/04, 15/042, 15/05, 15/0631, 15/0656, 15/14, 15/1459, 15/149, 2015/0053, 2015/012, 2015/016, 2015/018, 2015/0233, 2015/0288, 2015/035, 2015/045, 2015/055, 2015/1006, 2015/1016, 2015/1028, 2030/8813, 21/6486, 2201/061, 2458/00, 27/447, 27/44756, 30/0005, 33/487, 33/491, 33/4915, 33/5091
- G02B Optical elements, systems or apparatus: 21/32
- G21K Handling of particles or ionising radiation not otherwise provided for; irradiation devices; gamma ray or x-ray microscopes: 5/08
- H05H Plasma technique; production of accelerated electrically-charged particles or of neutrons; production or acceleration of neutral molecular or atomic beams: 3/04, 7/20
- Y10T Technical subjects covered by former us classification: 436/25375
- (73) Assignee
- ABS Global Inc
- (72) Inventors
- Daniel Mueth; Joseph Plewa; Jessica Shireman; Amy Anderson; Lewis Gruber; Neil Rosenbaum
- (54) Title
- Multiple laminar flow-based particle and cellular separation with laser steering
- (57) Abstract
The invention, provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
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Claims (9)
- An apparatus to identify at least one selected component from a plurality of components in a fluid mixture, the apparatus comprising: a sorting channel having a first inlet into which a first flow is introduced, the first flow which contains the plurality of component, a second inlet into which a secondary flow is introduced, a first outlet from which the first flow exit, and a second outlet from which at least a portion of the secondary flow exits; a region within the sorting channel, wherein a physical design of the region constricts the first flow and aligns the plurality of components, wherein the physical design of the region comprises a physical narrowing of a diameter in the region in a first direction; wherein the constriction of the first flow in the first direction is unaided by the secondary flow; wherein the selected component exits the apparatus through the second outlet; and wherein the unselected component exits the apparatus by an outlet other than the second outlet of the sorting channel.
- The apparatus of claim 1 wherein the region constricts a width of the flow as the flow travels through the region.
- The apparatus of claim 1, wherein the physical design exerts a pressure acting on the first flow.
- The apparatus of claim 3, wherein the pressure is orthogonal to the direction of the first flow.
- The apparatus of claim 3, wherein the pressure centers the plurality of components towards the center of the width of the flow.
- The apparatus of claim 1, wherein the first flow travels through the channel without aid of the secondary flow and wherein the channel is the sole channel for fluidic flow.
- The apparatus of claim 1, wherein the first flow travels through the channel without aid of the secondary flow of a sheath fluid or a buffer fluid.
- The apparatus of claim 1, further comprises a detector apparatus, wherein the detector apparatus determines a characteristic of each component among the plurality of components.
- The apparatus of claim 8, further comprises a selection apparatus, wherein each component is selected or unselected based on the characteristic of each component.
Description
The present invention relates generally to techniques and systems for separation of particulate or cellular materials such as blood, semen and other particles or cells into their various components and fractions, using multiple laminar flows which further may be coupled with laser steering such as holographic optical trapping and manipulation.
There are several categories of blood cells. Erythrocyte or red blood cell (RBC) counts are for women 4.8 million cells/μl and men 5.4 million cells/μl. RBCs make up 93% of the solid element in blood and about 42% of blood volume, Platelets are 2 μm-3 μm in size. They represent 7% of the solid elements in blood and about 3% of the blood volume, corresponding to about 1.5 to 4×10 11 cells per liter. There are 5 general types of white blood cells (WBCs) or leukocytes accounting for about 1.5 to 4×10 9 cells per liter. The WBCs comprise: 50-70% Neutrophils (12-15 μm in size); 2-4% Eosinophils (12-15 μm in size); 0.5-1% Basophils (9-10 μm in size); 20-40% Lymphocytes (25% B-cells and 75% T-cells) (8-10 μm in size); and 3-8% Monocytes (16-20 μm in size). They comprise 0.16% of the solid elements in the blood, and approximately 0.1% of the blood volume corresponding to around 4 to 12×10 9 per liter. A subject with an infection might have a WBC count as high as 25×10 9 per liter.
Platelets are the smallest cells in the blood and are important for releasing proteins into the blood that are involved in clotting.
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Record as JSON
{
"publication_number": "US11243494B2",
"country": "US",
"kind": "B2",
"title": "Multiple laminar flow-based particle and cellular separation with laser steering",
"abstract": "The invention, provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.",
"claims": [
"1. An apparatus to identify at least one selected component from a plurality of components in a fluid mixture, the apparatus comprising: a sorting channel having a first inlet into which a first flow is introduced, the first flow which contains the plurality of component, a second inlet into which a secondary flow is introduced, a first outlet from which the first flow exit, and a second outlet from which at least a portion of the secondary flow exits; a region within the sorting channel, wherein a physical design of the region constricts the first flow and aligns the plurality of components, wherein the physical design of the region comprises a physical narrowing of a diameter in the region in a first direction; wherein the constriction of the first flow in the first direction is unaided by the secondary flow; wherein the selected component exits the apparatus through the second outlet; and wherein the unselected component exits the apparatus by an outlet other than the second outlet of the sorting channel.",
"2. The apparatus of claim 1 wherein the region constricts a width of the flow as the flow travels through the region.",
"3. The apparatus of claim 1, wherein the physical design exerts a pressure acting on the first flow.",
"4. The apparatus of claim 3, wherein the pressure is orthogonal to the direction of the first flow.",
"5. The apparatus of claim 3, wherein the pressure centers the plurality of components towards the center of the width of the flow.",
"6. The apparatus of claim 1, wherein the first flow travels through the channel without aid of the secondary flow and wherein the channel is the sole channel for fluidic flow.",
"7. The apparatus of claim 1, wherein the first flow travels through the channel without aid of the secondary flow of a sheath fluid or a buffer fluid.",
"8. The apparatus of claim 1, further comprises a detector apparatus, wherein the detector apparatus determines a characteristic of each component among the plurality of components.",
"9. The apparatus of claim 8, further comprises a selection apparatus, wherein each component is selected or unselected based on the characteristic of each component."
],
"description_excerpt": "The present invention relates generally to techniques and systems for separation of particulate or cellular materials such as blood, semen and other particles or cells into their various components and fractions, using multiple laminar flows which further may be coupled with laser steering such as holographic optical trapping and manipulation.\n\nThere are several categories of blood cells. Erythrocyte or red blood cell (RBC) counts are for women 4.8 million cells/μl and men 5.4 million cells/μl. RBCs make up 93% of the solid element in blood and about 42% of blood volume, Platelets are 2 μm-3 μm in size. They represent 7% of the solid elements in blood and about 3% of the blood volume, corresponding to about 1.5 to 4×10 11 cells per liter. There are 5 general types of white blood cells (WBCs) or leukocytes accounting for about 1.5 to 4×10 9 cells per liter. The WBCs comprise: 50-70% Neutrophils (12-15 μm in size); 2-4% Eosinophils (12-15 μm in size); 0.5-1% Basophils (9-10 μm in size); 20-40% Lymphocytes (25% B-cells and 75% T-cells) (8-10 μm in size); and 3-8% Monocytes (16-20 μm in size). They comprise 0.16% of the solid elements in the blood, and approximately 0.1% of the blood volume corresponding to around 4 to 12×10 9 per liter. A subject with an infection might have a WBC count as high as 25×10 9 per liter.\n\nPlatelets are the smallest cells in the blood and are important for releasing proteins into the blood that are involved in clotting.",
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"assignees": [
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],
"inventors": [
"Daniel Mueth",
"Joseph Plewa",
"Jessica Shireman",
"Amy Anderson",
"Lewis Gruber",
"Neil Rosenbaum"
],
"filing_date": "2019-01-03",
"publication_date": "2022-02-08",
"grant_date": "2022-02-08",
"priority_date": "2002-07-31",
"application_number": "US-201916239297-A",
"family_id": "78825334",
"cited_by_count": 23,
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