Adenosine receptor antagonists

{
  "publication_number": "US4769377A",
  "country": "US",
  "kind": "A",
  "title": "Adenosine receptor antagonists",
  "abstract": "Novel 8-phenylxanthines which are potent adenosine receptor antagonists.",
  "claims": [
    "1. A compound of the formula ##STR4## or the pharmaceutically-acceptable salts, esters, amides, glycosides or formaldehyde complexes thereof, wherein: X is NH; R 1 is allyl or alkyl of 3 carbons; R 2 is allyl, or alkyl of 3 carbons; R 3 is H, NH 2 or OH; R 4 is phenyl, hydroxy or cycloalkoxy; and R 5, which may be the same or different, are hydrogen, lower alkyl, lower alkoxy, halogen, hydroxy, nitro or amino.",
    "2. The compound 8-(2-amino-4-chlorophenyl)theophylline.",
    "3. In a method involving adenosine receptor blocking by administering an adenosine receptor antagonist, the improvement which comprises using, as the antagonist, a compound according to claim 1."
  ],
  "cpc": [
    "C07D 473/08",
    "C07D 473/06"
  ],
  "assignees": [
    "UNIV JOHNS HOPKINS"
  ],
  "filing_date": "1986-02-03",
  "publication_date": "1988-09-06",
  "grant_date": "1988-09-06",
  "priority_date": "1983-02-18",
  "application_number": "US-82559486-A",
  "family_id": "27042215",
  "citations": [
    "DE1091570B",
    "GB982079A",
    "US3493573A",
    "US4452788A",
    "US4593095A",
    "US4612315A"
  ]
}