Acid addition salts of amidated taurine or glycine, their preparation and use

{
  "publication_number": "US5122520A",
  "country": "US",
  "kind": "A",
  "title": "Acid addition salts of amidated taurine or glycine, their preparation and use",
  "abstract": "Acid addition salt of taurine or glycine, their amino group being amidated with a carboxylic acid residue which contains the structure of a 3 alpha, 7 alpha, 12 alpha -trihydroxysteroid, their acid group being neutralized with the amino group of an aliphatic amine or neutralized with the amino group of a basic alpha -amino carboxylic acid which group is connected over an alkylene bridge with the alpha -amino acid group, may be used e.g. as transmucuous resorption promoter of drug compounds.",
  "claims": [
    "1. An acid addition salt of an anion (i) of taurine or glycine wherein the amino group thereof is substituted by an acyl group of a 3α,7α,12α-trihydroxy steroid carboxylic acid and a cation (ii) of either (a) an aliphatic amine any substituents of which are other than carboxyl groups or (b) a basic alpha amino acid having an alkylene bridge between the alpha amino acid group and another amino group.",
    "2. A salt of claim 1 wherein the anion is derived from taurocholic or glycocholic acid.",
    "3. A salt of claim 1 wherein the cation is derived from a basic alpha amino acid having an alkylene bridge between the alpha amino acid group and another amino group.",
    "4. A salt of claim 3 wherein the cation is derived from lysine.",
    "5. An acid addition salt of an anion of formula II ##STR7## in which R 1 =H or OH and R 2 =--CH 2 --COO - or --CH 2 --CH 2 --SO 3 - and a cation having the formula ##STR8##",
    "6. A salt of claim 5 wherein R 1 is hydrogen.",
    "7. A salt of claim 6 wherein R 2 is --CH 2 --CH 2 --SO 3 -.",
    "8. A pharmaceutical composition comprising at least one pharmacologically active agent and an acid addition salt of claim 1.",
    "9. A composition according to claim 8 wherein the pharmacologically active agent is a calcitonin.",
    "10. A composition according to claim 8 wherein the ratio of acid addition salt to pharmacologically active agent is from 1:1 to 5000:1.",
    "11. A composition according to claim 8 in unit dosage form containing from about 0.1 to 100 mg of the acid addition salt.",
    "12. A composition according to claim 8 in nasal form.",
    "13. A composition according to claim 8 comprising an acid addition salt of an anion of formula II ##STR9## wherein R 1 is hydrogen or hydroxy, and R 2 is --CH 2 --COO - or --CH 2 --CH 2 --SO 3 -, and a cation having the formula ##STR10##",
    "14. A composition according to claim 13 wherein R 1 is hydrogen.",
    "15. A composition according to claim 14 wherein R 2 is --CH 2 --CH 2 --SO 3 -."
  ],
  "cpc": [
    "A61K 47/28",
    "C07J 41/0061"
  ],
  "assignees": [
    "SANDOZ LTD"
  ],
  "filing_date": "1991-02-22",
  "publication_date": "1992-06-16",
  "grant_date": "1992-06-16",
  "priority_date": "1988-04-30",
  "application_number": "US-65978891-A",
  "family_id": "6353289",
  "citations": [
    "US3580936A",
    "US3839565A",
    "US3856953A",
    "US4104285A",
    "US4746508A"
  ]
}