Method for sterilization using a fluid chemical biocide

{
  "publication_number": "US5403549A",
  "country": "US",
  "kind": "A",
  "title": "Method for sterilization using a fluid chemical biocide",
  "abstract": "A method and a composition for disinfecting matter or materials such as medical instruments, operating rooms, examining tables, walls, windows, floors, solutions, porous substances and the like contaminated with bacteria, bacterial spores, fungi, or viruses is disclosed. The composition consists of a mixture of a peroxymonosulfate and a carbonyl-containing compound and reaction products thereof and is preferably dioxirane formed by in situ oxidation of a ketone or aldehyde by the peroxymonosulfate in aqueous solution. Carbonyl-containing compounds that have been tested include acetone, 2-pentanone, 4-hydroxy-4-methyl-2-pentanone, and camphorsulfonic acid. The method includes providing a solution containing the dioxirane reaction mixture and contacting the matter or materials with it at room temperature for a time sufficient to disinfect and sterilize the matter or materials.",
  "claims": [
    "1. A method for the disinfection and sterilization of material contaminated with one or more members selected from the group consisting of bacteria, bacterial spores, fungi and viruses, comprising the steps of: (a) providing a biocidal fluid containing a mixture of peroxymonosulfate and a ketone and reaction products thereof wherein the molar ratio of peroxymonosulfate to ketone is at least 0.01:1; and (b) contacting the material contaminated with one or more members selected from the group consisting of bacteria, bacterial spores, fungi and viruses with the biocidal fluid of step (a) for a time sufficient for disinfecting and sterilizing said material.",
    "2. The method of claim 1 wherein said molar ratio of peroxymonosulfate to ketone is between about 0.01:1 and 10:1.",
    "3. The method of claim 2 wherein said ketone is a member selected from the group consisting of acetone, 2-pentanone, 4-hydroxy-4-methyl-2-pentanone, and camphorsulfonic acid.",
    "4. The method of claim 3 wherein said biocidal fluid is a polar solution.",
    "5. The method of claim 4 wherein said biocidal fluid is an aqueous solution.",
    "6. The method of claim 5 wherein said ketone is acetone.",
    "7. The method of claim 5 wherein said ketone is 2-pentanone.",
    "8. The method of claim 5 wherein said ketone is 4-hydroxy-4-methyl-2-pentanone.",
    "9. The method of claim 5 wherein said ketone is camphorsulfonic acid.",
    "10. The method of claim 5 wherein said mixture of peroxymonosulfate and a ketone and reaction products thereof is present in said aqueous solution at a concentration between about 1% by weight and saturation.",
    "11. The method of claim 5 wherein said material contains a surface area which is to be disinfected and sterilized.",
    "12. The method of claim 11 wherein said material is a medical instrument.",
    "13. The method of claim 1 wherein said molar ratio of peroxymonosulfate to ketone is between about 0.1:1 and 3:1.",
    "14. The method of claim 2 wherein said biocidal fluid further comprises at least one compound selected from the group consisting of peroxides, aldehydes, epoxides and surfactants.",
    "15. The method of claim 1 wherein said biocidal fluid contains a dioxirane as one of said reaction products between said peroxymonosulfate and ketone.",
    "16. The method of claim 15 wherein said molar ratio of peroxymonosulfate to ketone is between about 0.01:1 and 10:1.",
    "17. The method of claim 16 wherein said ketone is a member selected from the group consisting of acetone, 2-pentanone, 4-hydroxy-4-methyl-2-pentanone, and camphorsulfonic acid and said dioxirane is a member selected from the group consisting of dimethyldioxirane, methyl-n-propyldioxirane, 4-hydroxy-4-methyl-2-pentadioxirane, and the dioxirane of camphorsulfonic acid.",
    "18. The method of claim 17 wherein said biocidal fluid is a polar solution.",
    "19. The method of claim 18 wherein said biocidal fluid is an aqueous solution.",
    "20. The method of claim 19 wherein said ketone is acetone and said dioxirane is dimethyldioxirane.",
    "21. The method of claim 19 wherein said ketone is 2-pentanone and said dioxirane is methyl-n-propyldioxirane.",
    "22. The method of claim 19 wherein said ketone is 4-hydroxy-4-methyl-2-pentanone and said dioxirane is 4-hydroxy-4-methyl-2-pentadioxirane.",
    "23. The method of claim 19 wherein said ketone is camphorsulfonic acid and said dioxirane is the dioxirane of camphorsulfonic acid.",
    "24. The method of claim 19 wherein said mixture of peroxymonosulfate and a ketone and dioxirane reaction product is present in said aqueous solution at a concentration between about 1% by weight and saturation.",
    "25. The method of claim 19 wherein said material contains a surface area which is to be disinfected and sterilized.",
    "26. The method of claim 25 wherein said material is a medical instrument.",
    "27. The method of claim 16 further comprising at least one compound selected from the group consisting of peroxides, aldehydes, epoxides and surfactants."
  ],
  "cpc": [
    "C07D 321/00",
    "A01N 43/24",
    "A01N 59/02",
    "Y02A 50/30"
  ],
  "assignees": [
    "CYCLO 3 PSS MEDICAL"
  ],
  "filing_date": "1993-11-04",
  "publication_date": "1995-04-04",
  "grant_date": "1995-04-04",
  "priority_date": "1993-11-04",
  "application_number": "US-14882993-A",
  "family_id": "22527587",
  "citations": [
    "US4376094A",
    "US5021182A"
  ]
}