Substituted amic acid derivatives

{
  "publication_number": "US5777150A",
  "country": "US",
  "kind": "A",
  "title": "Substituted amic acid derivatives",
  "abstract": "A compound of the formula (I) or its pharmaceutically acceptable salt or ester: ##STR1## wherein each of ##STR2## which are the same or different, is an aryl group or a heteroaromatic ring group; A is a C 3-8 linear saturated or unsaturated aliphatic hydrocarbon group which may have substituent(s) selected from the group consisting of a lower alkyl group, a hydroxyl group, a lower alkoxy group, a carboxyl group, an aryl group and an aralkyl group; Q is a single bond or a group of the formula --CO--O--, --O--CO--, --CH 2 CH 2 --, --CH═CH--, --OCH 2 --, --SCH 2 --, --CH 2 O-- or --CH 2 S--; each of R 1, R 2, R 3 and R 4 which are the same or different, is a hydrogen atom, a halogen atom, a lower alkyl group, a hydroxyl group, a lower alkoxy group, or an aryl or heteroaromatic ring group which may have substituent(s) selected from the group consisting of a halogen atom, a lower alkyl group and a lower alkoxy group; each of R 5, R 6 and R 7 which are the same or different, is a hydrogen atom or a lower alkyl group; and R 8 is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or an aralkyl group, provided that when Q is a single bond, ##STR3## are not simultaneously 4-chlorophenyl groups.",
  "claims": [
    "1. A compound of the formula (III-b 1): ##STR83## wherein each of R 12 and R 13, which are the same or different, is a carboxyl-protecting group, or the formula (III-b 2): ##STR84## wherein R 12 and R 13 are as defined above.",
    "2. The compound of claim 1, which has the formula (III-b 1).",
    "3. The compound of claim 1, which has the formula (III-b 2).",
    "4. The compound of claim 1, wherein said carboxyl-protecting group is selected from the group consisting of alkyl, halo-substituted lower alkyl, lower alkanoyloxyalkyl, lower alkoxycarbonyloxyalkyl, lower alkenyl, lower aralkyl, 5-methyl-2-oxyl-1,3-dioxyl-4-yl methyl, lower alkylsilyl, indanyl, phthalidyl and methoxymethyl.",
    "5. The compound of claim 1, wherein said carboxyl-protecting group is selected from the group consisting of methyl, ethyl, propyl, iso-propyl, tert-butyl, 2,2,2-trichloroethyl, 2,2,2-trifluoroethyl, acetoxymethyl, propionyloxymethyl, pivaloyloxymethyl, 1-acetoxyethyl, 1-pivaloyloxyethyl, 1-(methoxycarbonyloxy)ethyl, 1-(ethoxycarbonyloxy)ethyl, 1-(isopropoxycarbonyloxy)ethyl, 2-propenyl, 2-chloro-2-propenyl, 3-methoxycarbonyl-2-propenyl, 2-methyl-2-propenyl, 2-butenyl, cinnanyl, benzyl, p-methoxybenzyl, 3,4-dimethoxybenzyl, o-nitrobenzyl, p-nitrobenzyl, benzhydryl, bis(p-methoxyphenyl)methyl, trityl, 5-methyl-2-oxo-1,3-dioxol-4-yl)methyl, trimethylsilyl, tert-butyldimethylsilyl, indanyl, phthalidyl and methoxymethyl.",
    "6. The compound of claim 4, wherein said carboxyl-protecting group is selected from the group consisting of methyl, ethyl, tert-butyl, 2-propenyl, benzyl, p-methoxybenzyl, benzhydryl and trityl.",
    "7. The compound of claim 1, wherein said carboxyl-protecting group is selected from the group consisting of halo-substituted lower alkyl, lower alkanoyloxyalkyl, lower alkoxycarbonyloxyalkyl, lower alkenyl, aralkyl, 5-methyl-2-oxyl-1,3-dioxyl-4-yl methyl, indanyl, phthalidyl and methoxymethyl.",
    "8. The compound of claim 7, wherein said carboxyl-protecting group is selected from the group consisting of 2-propenyl, benzyl, p-methoxybenzyl, benzhydryl and trityl."
  ],
  "cpc": [
    "C07D 213/40",
    "C07C 211/27",
    "C07C 211/29",
    "C07C 215/52",
    "C07C 217/60",
    "C07C 233/05",
    "C07C 233/13",
    "C07C 233/18",
    "C07C 235/06",
    "C07C 69/34",
    "C07D 213/38",
    "C07D 215/12",
    "C07D 215/48",
    "C07D 263/32",
    "C07D 307/14",
    "C07D 307/52",
    "C07D 307/81",
    "C07D 317/58",
    "C07D 333/20",
    "C07D 333/28",
    "C07D 333/54",
    "C07D 333/58"
  ],
  "assignees": [
    "BANYU PHARMA CO LTD"
  ],
  "filing_date": "1996-08-13",
  "publication_date": "1998-07-07",
  "grant_date": "1998-07-07",
  "priority_date": "1993-02-12",
  "application_number": "US-69615296-A",
  "family_id": "27292953"
}