Solid pharmaceutical dispersions

{
  "publication_number": "US5837714A",
  "country": "US",
  "kind": "A",
  "title": "Solid pharmaceutical dispersions",
  "abstract": "This invention provides solid pharmaceutical dispersions comprising a poorly soluble drug substance, as SR48692 or naproxen, xylitol and Transcutol, and a method of preparing such dispersions comprising the steps of dissolving the poorly soluble drug substance in Transcutol and adding the solution to xylitol. The dispersions exhibit good pharmaceutical properties and reduced levels of impurities and degradation products.",
  "claims": [
    "1. A solid dispersion comprising: a) a poorly soluble drug substance selected from the group consisting of SR48692 and naproxyn: b) xylitol and c) Transcutol.",
    "2. The solid dispersion of claim 1 wherein said drug substance is SR48692.",
    "3. The solid dispersion of claim 1 wherein said drug substance is naproxyn.",
    "4. The solid dispersion of claim 1 further comprising a base.",
    "5. The solid dispersion of claim 2 further comprising a base.",
    "6. The solid dispersion of claim 3 further comprising a base.",
    "7. A method of preparing a dispersion comprising the steps of: a) dissolving a poorly soluble drug substance selected from the group consisting of SR48692 and naproxyn in Transcutol; b) adding the solution to xylitol."
  ],
  "cpc": [
    "A61K 31/00",
    "A61K 31/192",
    "A61K 31/4709",
    "A61K 9/2009",
    "A61K 9/2013",
    "A61K 9/2018"
  ],
  "assignees": [
    "SANOFI SA"
  ],
  "filing_date": "1997-03-03",
  "publication_date": "1998-11-17",
  "grant_date": "1998-11-17",
  "priority_date": "1997-03-03",
  "application_number": "US-81394697-A",
  "family_id": "25213825",
  "citations": [
    "US5420141A",
    "WO8802625A1"
  ]
}