Method for controlling weight with hypericum perforatum and garcinia cambogia

{
  "publication_number": "US5911992A",
  "country": "US",
  "kind": "A",
  "title": "Method for controlling weight with hypericum perforatum and garcinia cambogia",
  "abstract": "A method of controlling weight in mammals by orally administering to the mammal an amount of a pharmaceutical composition containing Hypericum perforatum or active components thereof effective to control the weight of the mammal is described. The pharmaceutical composition also preferably further contains at least one thermogenic agent and at least one agent inhibiting lipogenesis. The at least one thermogenic agent includes one or more of N-acetyl-L-carnitine, cayenne extract, inositol hexanicotinate, niacin or salicin. The at least one agent inhibiting lipogenesis may be hydroxy citric acid. When the pharmaceutical composition includes Hypericum perforatum, at least one thermogenic agent and at least one agent inhibiting lipogenesis, the composition acts to control the weight of the mammal by simultaneously suppressing appetite, inducing thermogenesis and inhibiting lipogenesis.",
  "claims": [
    "1. A method of preventing weight gain and facilitating weight loss in a mammal, comprising orally administering to the mammal an amount of a composition effective to prevent weight gain and facilitate weight loss in the mammal, the composition comprising Hypericum perforatum or an extract of leaves or flowers thereof containing hypericin, and Garcinia cambogia or an extract thereof containing hydroxy citric acid as an agent inhibiting lipogenesis, wherein the composition is administered in an amount such that the total daily amount of Hypericum perforatum or an extract of leaves or flowers thereof containing hypericin administered ranges from 100 to 2,000 mg and the total daily amount of Garcinia cambogia or an extract thereof containing hydroxy citric acid administered ranges from 100 to 1,000 mg.",
    "2. A method according to claim 1, wherein the composition further comprises a pharmaceutically acceptable carrier.",
    "3. A method according to claim 1, wherein the composition is administered in an amount of two to four single doses per day.",
    "4. A method according to claim 1, wherein the composition is administered in tablet or capsule form, and wherein each tablet or capsule contains a total of between 100 and 1,500 mg of both Hypericum perforatum or an extract of leaves or flowers thereof containing hypericin and Garcinia cambogia or an extract thereof containing hydroxy citric acid.",
    "5. A method according to claim 1, wherein the composition further comprises inositol hexanicotinate and pyridoxyl phosphate such that the inositol hexanicotinate is administered in a total daily amount of from 250 to 1,000 mg and pyridoxyl phosphate is administered in a total daily amount of from 100 to 500 mg.",
    "6. A method according to claim 1, wherein the composition further comprises at least one thermogenic agent selected from the group consisting of N-acetyl-L-carnitine, cayenne extract, inositol hexanicotinate, niacin and salicin.",
    "7. A method according to claim 6, wherein the composition is administered in an amount such that the total daily amount of thermogenic agent administered ranges from 100 to 2,000 mg.",
    "8. A method of preventing weight gain and facilitating weight loss in a mammal, comprising orally administering to the mammal an amount of a composition effective to prevent weight gain and facilitate weight loss in the mammal, the composition comprising one or both of hypericin and pseudohypericin administered in an amount such that the total daily amount administered ranges from 100 to 2,000 mg, and hydroxy citric acid administered in an amount such that the total daily amount administered ranges from 100 to 1,000 mg.",
    "9. A composition comprising Hypericum perforatum or an extract of leaves or flowers thereof containing hypericin, at least one thermogenic agent selected from the group consisting of N-acetyl-L-camitine, cayenne extract, inositol hexanicotinate, niacin and salicin and Garcinia cambogia or an extract thereof containing hydroxy citric acid as an agent inhibiting lipogenesis, wherein the Hypericum perforatum or an extract of leaves or flowers thereof containing hypericin is present in an amount of 50 to 500 mg, the at least one thermogenic agent is present in an amount of 100 to 1,000 mg, and the agent inhibiting lipogenesis is present in an amount of 50 to 500 mg.",
    "10. A composition according to claim 9, wherein the salicin is derived from white willow bark extract.",
    "11. A composition according to claim 9, wherein the composition further comprises a pharmaceutically acceptable carrier.",
    "12. A composition according to claim 9, wherein the composition contains inositol hexanicotinate as the thermogenic agent and further comprises pyridoxyl phosphate.",
    "13. A composition according to claim 9, wherein the composition further comprises one or more of 5-hydroxy tryptamine, tryptophan, L-phenylalanine, L-tyrosine, calcium carbonate or magnesium oxide.",
    "14. A composition according to claim 12, wherein the composition further comprises salicin.",
    "15. A composition according to claim 9, wherein the composition is in a form of a tablet or capsule.",
    "16. A composition comprising one or both of hypericin and pseudohypericin in an amount of 50 to 500 mg, at least one thermogenic agent selected from the group consisting of N-acetyl-L-carnitine, cayenne extract, inositol hexanicotinate, niacin and salicin in an amount of 100 to 1,000 mg and hydroxy citric acid in an amount of 50 to 500 mg as an agent inhibiting lipogenesis."
  ],
  "cpc": [
    "A61K 36/38"
  ],
  "assignees": [
    "GLENN BRASWELL A"
  ],
  "filing_date": "1997-06-12",
  "publication_date": "1999-06-15",
  "grant_date": "1999-06-15",
  "priority_date": "1997-06-12",
  "application_number": "US-87403397-A",
  "family_id": "25362843",
  "citations": [
    "EP0599307A1",
    "EP0803202A2",
    "JPH0951779A",
    "US5273754A",
    "US5612039A",
    "WO9308186A1"
  ]
}