Method of deposition a dry powder and dispensing device

{
  "publication_number": "US6146685A",
  "country": "US",
  "kind": "A",
  "title": "Method of deposition a dry powder and dispensing device",
  "abstract": "A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.",
  "claims": [
    "1. A method of depositing dielectric elongated pharmaceutical active medicament dry powder particles on a substrate comprising: providing a plurality of said dielectric elongated pharmaceutical active medicament dry particles each having a longitudinal axis; and depositing the particles on a surface of the substrate with the longitudinal axes aligned substantially normal to the substrate surface, the particles being attracted to the substrate by an electric field so as to minimize agglomeration of the particles and to minimize adherence of the particles to the substrate.",
    "2. The method of claim 1 including charging the particles with a given polarity and electrostatically depositing the particles on the substrate.",
    "3. The method of claim 2 including providing the particles with an aspect ratio such that an electrical dipole is created in each particle along its longitudinal axis such that an electrical field electrostatically attracts and aligns the particles to the substrate.",
    "4. The method of claim 1 wherein the particles have an aspect ratio of about 2:1.",
    "5. The method of claim 1 including providing a metal substrate.",
    "6. The method of claim 5 including providing a stainless steel substrate.",
    "7. The method of claim 1 including depositing a controlled amount of the particles at each of a plurality of predetermined regions on the surface of the substrate to form a unit dosage at each said predetermined region.",
    "8. The method of claim 1 including the step of forming particle chains substantially normal to the substrate.",
    "9. The method of claim 1 including providing particles with a diametrical dimension in the range of about 0.5 to 3 μm and a length in the range of about 1 to 10 μm.",
    "10. The method of claim 1 including the step of providing a plurality of the particles in a plurality of separate discrete locations on the substrate, each location forming a dosage."
  ],
  "cpc": [
    "B05D 1/06",
    "A61K 9/00",
    "A61K 9/0075",
    "A61M 11/001",
    "A61M 15/0043",
    "A61M 15/0045",
    "A61M 15/0051",
    "A61M 15/0055",
    "A61M 15/02",
    "A61M 2202/064"
  ],
  "assignees": [
    "DELSYS PHARMACEUTICAL CORP"
  ],
  "filing_date": "1998-11-05",
  "publication_date": "2000-11-14",
  "grant_date": "2000-11-14",
  "priority_date": "1998-11-05",
  "application_number": "US-18709298-A",
  "family_id": "22687570",
  "citations": [
    "CA452052A",
    "US5470603A",
    "US5714007A",
    "WO9309832A1"
  ]
}