Bilayer structure which encapsulates multiple containment units and uses thereof

{
  "publication_number": "US6221401B1",
  "country": "US",
  "kind": "B1",
  "title": "Bilayer structure which encapsulates multiple containment units and uses thereof",
  "abstract": "The present invention provides a bilayer structure for encapsulating multiple containment units. These containment units can attach or contain therapeutic or diagnostic agents that can be released through the bilayer structure. A suitable example of such a containment unit is a unilamellar or multilamellar vesicle.",
  "claims": [
    "1. A composition comprising a bilayer structure and multiple containment units, the bilayer structure encapsulating the multiple containment units and which outer bilayer structure is generated from cochleated cylinders and is distinct from the multiple containment units.",
    "2. The composition of claim 1, wherein the containment units are aggregated within the bilayer structure.",
    "3. The composition of claim 1, wherein the multiple containment units include a therapeutic agent.",
    "4. The composition of claim 1, wherein the multiple containment units include a diagnostic agent.",
    "5. A vesosome having a bilayer structure and multiple vesicles, the bilayer structure encapsulating the multiple vesicles and which outer bilayer structure is generated from cochleated cylinders and is distinct from the multiple vesicles.",
    "6. The vesosome of claim 5, wherein the vesicles are aggregated within the bilayer structure.",
    "7. The vesosome of claim 5, wherein the multiple vesicles are of different size.",
    "8. The vesosome of claim 5, wherein the multiple vesicles are of the same size.",
    "9. The vesosome of claim 5, wherein the multiple vesicles include a therapeutic agent.",
    "10. The vesosome of claim 5, wherein the multiple vesicles include a diagnostic agent.",
    "11. A method for encapsulating multiple containment units within a bilayer structure comprising: a. obtaining aggregated multiple containment units in a solution; b. adding cochleated cylinders to the solution; and c. mixing the aggregated multiple containment units of step (a) and the cochleated cylinders of step (b) in the solution under suitable conditions so that the cochleated cylinders transform to create the bilayer structure that encapsulates the aggregated multiple containment units.",
    "12. A method for delivering a therapeutic agent to a target site that comprises introducing the vesosome of claim 9 to the target site under conditions so that the therapeutic agent is released therefrom.",
    "13. The method of claim 12, wherein the vesosome is introduced by intramuscular injection, intravenous injection, oral administration, pulmonary adsorption, rectal, nasal, oral, ocular, vaginal, or uretheral administration, subcutaneous injection, sublingual administration, or topical application.",
    "14. A method for delivering a therapeutic agent to a target site that comprises introducing the composition of claim 3 to the target site under conditions so that the therapeutic agent is released therefrom.",
    "15. The method of claim 14, wherein the composition is introduced by intramuscular injection, intravenous injection, oral administration, pulmonary adsorption, rectal, nasal, oral, ocular, vaginal, or uretheral administration, subcutaneous injection, sublingual administration, or topical application.",
    "16. The method of claim 12 or 14, wherein the therapeutic agent is a drug acting at synaptic and neuroeffector junctional sites.",
    "17. The method of claim 16, wherein the drug is selected from a group consisting of a neurohumoral transmitter, a cholinergic agonist, an anticholinesterase agent, an antimuscarinic drug, an agent acting at the neuromuscular junction and autonomic ganglia, a catecholamine, a sympathomimetic drug, and an adrenergic receptor antagonist.",
    "18. The method of claim 12 or 14, wherein the therapeutic agent is a drug acting on the CNS.",
    "19. The method of claim 18, wherein the drug is selected from a group consisting of an antipsychotic drug, a neuroleptic drug, tricyclic antidepressants, monoamine oxidase inhibitors, lithium salts, and benzodiazepines.",
    "20. The method of claim 12 or 14, wherein the therapeutic agent is a drug which reduces inflammation.",
    "21. The method of claim 20, wherein the drug is selected from a group consisting of antagonists of histamine, bradykinin, 5-hydroxytryptamine; lipid-derived autacoids; methylxanthines, cromolyn sodium; analgesic-antipyretics.",
    "22. The method of claim 12 or 14, wherein the therapeutic agent is a drug which affects renal function and electrolyte metabolism.",
    "23. The method of claim 22, wherein the drug is selected from a group consisting of diuretics and inhibitors of tubular transport of organic compounds.",
    "24. The method of claim 12 or 14, wherein the therapeutic agent is a drug which affects cardiovascular function.",
    "25. The method of claim 24, wherein the drug is selected from a group consisting of renin and angiotensin; organic nitrates, calcium-channel blockers and beta-adrenergic antagonists; antihypertensive agents, digitalis, antiarrhythmic drugs, and drugs used in the treatment of hyperlipoproteinemias.",
    "26. The composition of claim 2, wherein the aggregation of the containment units is by ligand-receptor interaction.",
    "27. The composition of claim 6, wherein the aggregation of the vesicles is by ligand-receptor interaction."
  ],
  "cpc": [
    "A61K 9/1274",
    "Y10S 977/907",
    "Y10S 977/927"
  ],
  "assignees": [
    "UNIV CALIFORNIA"
  ],
  "filing_date": "1998-08-24",
  "publication_date": "2001-04-24",
  "grant_date": "2001-04-24",
  "priority_date": "1996-12-02",
  "application_number": "US-13904598-A",
  "family_id": "26708242",
  "citations": [
    "US4078052A",
    "US5004566A",
    "US5492696A",
    "US5576017A",
    "US5618560A",
    "US5643574A",
    "US5723147A"
  ]
}