MLchartDataset catalogue

Patent · US6268207B1 · B1 · US

Enzymatic resolution of 1-amino-2-vinylcyclopropyl caboxylic acid methyl ester

(11) Publication number
US6268207B1
(21) Application number
US-66003000-A
(22) Filing date
2000-09-12
(30) Priority date
1998-08-10
(43) Publication date
2001-07-31
(45) Date of grant
2001-07-31
(52) CPC
  • C12P Fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture {}: 13/02, 41/005
  • A61K Preparations for medical, dental or toiletry purposes: 38/21, 45/06
  • A61P Specific therapeutic activity of chemical compounds or medicinal preparations: 1/16, 31/12, 31/14, 31/16, 43/00
  • C07D Heterocyclic compounds: 207/16, 401/12, 403/12, 403/14, 405/14, 409/14, 417/14
  • C07K Peptides: 5/08, 5/0806, 5/0808, 5/081, 5/0812
(73) Assignee
BOEHRINGER INGELHEIM CA LTD
(54) Title
Enzymatic resolution of 1-amino-2-vinylcyclopropyl caboxylic acid methyl ester
(57) Abstract

An enantiomeric-resolving process for obtaining (1R,2S)-1-amino-2-vinylcyclopropyl carboxylic acid methyl ester by use of an esterase, and especially Alcalase(R), is disclosed.

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Claims (2)

  1. A process for the resolution of enantiomers from a mixture of (1R,2S)/(1S,2S)-1-amino-2-vinylcyclopropyl carboxylic acid methyl ester, comprising the step of treating said mixture with an esterase to obtain the corresponding (1R,2S) enantiomer.
  2. A process according to claim 1, wherein said esterase is Alcalase®.

Citations (3)

  • DE19600034A1
  • WO9817679A1
  • WO9907733A2
Record as JSON 
{
  "publication_number": "US6268207B1",
  "country": "US",
  "kind": "B1",
  "title": "Enzymatic resolution of 1-amino-2-vinylcyclopropyl caboxylic acid methyl ester",
  "abstract": "An enantiomeric-resolving process for obtaining (1R,2S)-1-amino-2-vinylcyclopropyl carboxylic acid methyl ester by use of an esterase, and especially Alcalase(R), is disclosed.",
  "claims": [
    "1. A process for the resolution of enantiomers from a mixture of (1R,2S)/(1S,2S)-1-amino-2-vinylcyclopropyl carboxylic acid methyl ester, comprising the step of treating said mixture with an esterase to obtain the corresponding (1R,2S) enantiomer.",
    "2. A process according to claim 1, wherein said esterase is Alcalase®."
  ],
  "cpc": [
    "C12P 13/02",
    "A61K 38/21",
    "A61K 45/06",
    "A61P 1/16",
    "A61P 31/12",
    "A61P 31/14",
    "A61P 31/16",
    "A61P 43/00",
    "C07D 207/16",
    "C07D 401/12",
    "C07D 403/12",
    "C07D 403/14",
    "C07D 405/14",
    "C07D 409/14",
    "C07D 417/14",
    "C07K 5/08",
    "C07K 5/0806",
    "C07K 5/0808",
    "C07K 5/081",
    "C07K 5/0812",
    "C12P 41/005"
  ],
  "assignees": [
    "BOEHRINGER INGELHEIM CA LTD"
  ],
  "filing_date": "2000-09-12",
  "publication_date": "2001-07-31",
  "grant_date": "2001-07-31",
  "priority_date": "1998-08-10",
  "application_number": "US-66003000-A",
  "family_id": "26790767",
  "citations": [
    "DE19600034A1",
    "WO9817679A1",
    "WO9907733A2"
  ]
}

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