up-and-down procedure (UDP)

{
  "id": "MLC-T-AGR-006601",
  "term": "up-and-down procedure (UDP)",
  "field": "Agriculture and food",
  "definition": "This test is an alternative to the Median Lethal Dose (LD50) test in which animals are used for acute toxicity testing. Animals are dosed one at a time with a drug or toxic substance. If an animal survives, the dose for the next animal is increased; if it dies, the dose is decreased to determine toxicity level.",
  "subject": "Animals, Livestock, One Health",
  "see_also": [
    "computational toxicology"
  ],
  "references": [
    "Based upon Bruce R. D. (1985). An up-and-down procedure for acute toxicity testing. Fundamental and applied toxicology : official journal of the Society of Toxicology, 5(1), 151-157.",
    "NAL Agricultural Thesaurus and Glossary"
  ],
  "translations": {
    "es": "procedimiento de subida y bajada (UDP)"
  },
  "url": "https://mlchart.com/terminology/agriculture/up-and-down-procedure-udp/"
}