Bapotulimab

{
  "id": "MLC-T-ONC-011875",
  "term": "Bapotulimab",
  "field": "Oncology and biomedicine",
  "definition": "A mouse/human cross-reactive immunoglobulin G2 (IgG2) monoclonal antibody against the immune checkpoint immunoglobulin-like domain containing receptor 2 (ILDR2; Chromosome 1 Open Reading Frame 32; C1orf32), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, bapotulimab targets, binds to and inhibits ILDR2, thereby blocking the immunosuppressive activity of ILDR2. This prevents ILDR2-mediated inhibition of T-cell activities and induces a cytotoxic T-lymphocyte (CTL) response against tumor cells. ILDR2, a type I transmembrane protein belonging to the B7 family of immunomodulatory receptors, negatively regulates T-cell responses.",
  "synonyms": [
    "anti-immunoglobulin-like domain containing receptor 2 MoAb BAY1905254",
    "anti-ILDR2 inhibitor BAY1905254",
    "immune checkpoint inhibitor BAY1905254",
    "ILDR2 function-blocking antibody BAY1905254",
    "anti-ILDR2 monoclonal antibody BAY 1905254"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bapotulimab/"
}