Becatecarin

{
  "id": "MLC-T-ONC-011928",
  "term": "Becatecarin",
  "field": "Oncology and biomedicine",
  "definition": "A synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis.",
  "synonyms": [
    "rebeccamycin analogue",
    "rebeccamycin analogue, tartrate salt",
    "DEAE-rebeccamycin"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/becatecarin/"
}