Bexarotene

{
  "id": "MLC-T-ONC-001019",
  "term": "Bexarotene",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat skin problems caused by cutaneous T-cell lymphoma that did not get better after other treatment. It is also being studied in the treatment of other types of cancer. Bexarotene binds to and activates proteins called retinoid X receptors, which may stop the growth of cancer cells and kill them. It is a type of retinoid. Also called LGD1069 and Targretin.",
    "A synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties. Bexarotene selectively binds to and activates retinoid X receptors (RXRs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression."
  ],
  "synonyms": [
    "LGD1069",
    "Targretin",
    "3-methyl TTNEB"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bexarotene/"
}