bocodepsin besylate

{
  "id": "MLC-T-ONC-012064",
  "term": "bocodepsin besylate",
  "field": "Oncology and biomedicine",
  "definition": "The besylate form of bocodepsin, an orally bioavailable inhibitor of the histone deacetylase (HDAC) subtypes 1 and 4, with potential antineoplastic activity. Upon administration,bocodepsin targets, binds to and inhibits the activity of HDAC1/4. This results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. This consequently results in a selective transcription of tumor suppressor genes, tumor suppressor protein-mediated inhibition of tumor cell division and an induction of apoptosis in tumor cells that overexpress HDAC1/4. HDAC, which is upregulated in many tumor cell types, deacetylates chromatin histone proteins and plays a key role in transcriptional regulation and cell cycle progression.",
  "synonyms": [
    "class-1/4 HDACi OKI-179",
    "HDAC inhibitor OKI-179",
    "HDAC1/4i OKI-179",
    "HDACi 1/4 OKI-179",
    "HDACi OKI-179"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bocodepsin-besylate/"
}