busulfan

{
  "id": "MLC-T-ONC-001305",
  "term": "busulfan",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used under the brand name Myleran to treat chronic myelogenous leukemia (CML) and with other drugs under the brand name Busulfex to prepare patients with CML for a donor stem cell transplant. It is also being studied in the treatment of other types of cancer. Busulfan damages the cell’s DNA and may kill cancer cells. It is a type of alkylating agent.",
    "A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription."
  ],
  "abbreviation": "BUS",
  "synonyms": [
    "myeloleukon",
    "myelosan",
    "mylecytan",
    "busulphan",
    "bussulfam",
    "busulfanum",
    "glyzophrol",
    "myeleukon",
    "sulfabutin",
    "tetramethylene bis(methanesulfonate)",
    "joacamine",
    "methanesulfonic acid tetramethylene ester"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/busulfan/"
}