EDB-FN-targeting gadolinium-based contrast agent MT218

{
  "id": "MLC-T-ONC-013208",
  "term": "EDB-FN-targeting gadolinium-based contrast agent MT218",
  "field": "Oncology and biomedicine",
  "definition": "A contrast agent composed of a peptide of seven amino acids targeting the extradomain B (EDB) of fibronectin (FN) conjugated to the contrast agent gadolinium, with potential contrast-enhancing activity upon magnetic resonance (MR) imaging. Upon administration of EDB-FN-targeting gadolinium-based contrast agent MT218, the EDB-FN-targeting peptide moiety targets and binds to EDB-FN overexpressed on various tumor cells. Upon MRI, gadolinium produces a large magnetic moment and thus a large local magnetic field. This enhances the relaxation rate of nearby protons and increases the signal intensity of tissue images. This allows visualization and specific localization of EDB-FN-expressing tumor cells. EDB of fibronectin, an oncogenic extracellular matrix protein, is expressed in many aggressive solid human tumors, whereas it is not detectable in normal vessels and tissues.",
  "synonyms": [
    "fibronectin-targeting gadolinium-based contrast agent MT218",
    "gadolinium-based contrast agent MT218",
    "GBCA MT218",
    "peptidic gadolinium-based MR imaging agent MT218",
    "ZD2-N3-Gd(HP-DO3A)"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/edb-fn-targeting-gadolinium-based-contrast-agent-mt218/"
}