EGF vaccine EGF-PTI

{
  "id": "MLC-T-ONC-013235",
  "term": "EGF vaccine EGF-PTI",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine containing epidermal growth factor (EGF), with immunomodulating and antineoplastic activities. Upon administration of the EGF vaccine EGF-PTI, EGF induces an immune response against EGFR, which results in the formation of anti-EGF-specific neutralizing antibodies. This causes binding of the anti-EGF antibodies to endogenous EGF, reduces levels of circulating EGF and prevents the binding of EGF to its receptor EGFR. This prevents EGF/EGFR pathway activation and may result in an inhibition of proliferation in EGFR-overexpressing tumor cells. EGF/EGFR-mediated signaling is overactivated in certain cancer types and drives tumor cell proliferation and progression.",
  "synonyms": [
    "EGF-PTI",
    "EGF pathway targeted immunization agent",
    "EGF pathway targeted immunotherapy agent",
    "EGF pathway-targeted immunotherapeutic"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/egf-vaccine-egf-pti/"
}