EGFR inhibitor NRC-2694 dihydrochloride

{
  "id": "MLC-T-ONC-013248",
  "term": "EGFR inhibitor NRC-2694 dihydrochloride",
  "field": "Oncology and biomedicine",
  "definition": "The dihydrochloride salt form of NRC-2694, an orally bioavailable, small-molecule inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, EGFR inhibitor NRC-2694 binds to and inhibits EGFR, which prevents EGFR-mediated signaling and leads to cell death in EGFR-expressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/egfr-inhibitor-nrc-2694-dihydrochloride/"
}