EGFR inhibitor TY-9591

{
  "id": "MLC-T-ONC-013250",
  "term": "EGFR inhibitor TY-9591",
  "field": "Oncology and biomedicine",
  "definition": "An orally available inhibitor of epidermal growth factor receptor (EGFR), including activating mutations, with potential antineoplastic activity. Upon administration, the EGFR inhibitor TY-9591 binds to and inhibits EGFR activating mutations, including the resistance mutation T790M, which prevents EGFR mutant-mediated signaling and leads to cell death in EGFR mutant-expressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.",
  "synonyms": [
    "EGFR tyrosine kinase inhibitor TY-9591"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/egfr-inhibitor-ty-9591/"
}