EGFR T790M antagonist BPI-15086

{
  "id": "MLC-T-ONC-013268",
  "term": "EGFR T790M antagonist BPI-15086",
  "field": "Oncology and biomedicine",
  "definition": "An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. EGFR T790M antagonist BPI-15086 specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.",
  "synonyms": [
    "EGFR T790M inhibitor BPI-15086"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/egfr-t790m-antagonist-bpi-15086/"
}