elimusertib

{
  "id": "MLC-T-ONC-013303",
  "term": "elimusertib",
  "field": "Oncology and biomedicine",
  "definition": "An orally available ataxia telangiectasia and Rad3-related (ATR)-specific kinase inhibitor, with potential antineoplastic activity. Upon oral administration, elimusertib selectively binds to and inhibits the activity of ATR, which prevents ATR-mediated signaling. This inhibits DNA damage checkpoint activation, disrupts DNA damage repair and induces apoptosis in ATR-overexpressing tumor cells. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression and cell survival.",
  "synonyms": [
    "ATR kinase inhibitor BAY1895344",
    "ATR inhibitor BAY1895344"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/elimusertib/"
}