enteric-coated TRPM8 agonist D-3263 hydrochloride

{
  "id": "MLC-T-ONC-013366",
  "term": "enteric-coated TRPM8 agonist D-3263 hydrochloride",
  "field": "Oncology and biomedicine",
  "definition": "An enteric-coated orally bioavailable formulation of the hydrochloride salt of a small-molecule agonist for transient receptor potential melastatin member 8 (TRPM8 or Trp-p8) with potential antineoplastic activity. The active ingredient in enteric-coated TRPM8 agonist D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. This agent may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH. TRPM8 is a transmembrane calcium channel protein that is normally expressed in prostate cells and appears to be overexpressed in benign prostatic hyperplasia (BPH) and in prostate cancer.",
  "synonyms": [
    "EC D-3263 HCl"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/enteric-coated-trpm8-agonist-d-3263-hydrochloride/"
}