erdafitinib-releasing intravesical system TAR-210

{
  "id": "MLC-T-ONC-013406",
  "term": "erdafitinib-releasing intravesical system TAR-210",
  "field": "Oncology and biomedicine",
  "definition": "A controlled-release intravesical system consisting of a pretzel-shaped tube releasing erdafitinib, a pan fibroblast growth factor receptor (FGFR) inhibitor, with potential antineoplastic activity. Upon placement of the erdafitinib-releasing intravesical system TAR-210 into the bladder, erdafitinib is gradually and continuously released from the system over an extended period of time before being removed from the bladder. Upon release, erdafitinib targets, binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways and thus the inhibition of tumor cell proliferation and tumor cell death in FGFR-overexpressing tumor cells. FGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival.",
  "synonyms": [
    "intravesical erdafitinib TAR-210"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/erdafitinib-releasing-intravesical-system-tar-210/"
}