FAP/CD40-targeting DARPin MP0317

{
  "id": "MLC-T-ONC-013529",
  "term": "FAP/CD40-targeting DARPin MP0317",
  "field": "Oncology and biomedicine",
  "definition": "A tri-specific, designed ankyrin repeat proteins (DARPin)-based agent targeting the tumor-associated protein fibroblast activation protein (FAP), CD40 receptor and human serum albumin (HSA), with potential immunostimulatory and antineoplastic activities. Upon administration, FAP/CD40-targeting DARPin MP0317 targets and binds to both FAP, localized predominantly on cancer-associated fibroblasts (CAFs) in the tumor stroma, and CD40, a cell surface stimulatory receptor expressed on various immune cells including B lymphocytes, monocytes and dendritic cells (DCs). The simultaneous binding to FAP and CD40 results in local clustering of FAP-expressing tumor stromal cells and CD40-expressing immune cells. Activation of CD40 induces proliferation and activation of B lymphocytes, shifts the induction of suppressive macrophages towards immunostimulatory macrophages, activates monocyte-derived DCs (moDCs), and leads to the secretion of inflammatory cytokines, which activates the immune system to induce the proliferation and activation of cytotoxic T lymphocytes (CTLs) against tumor cells. CD40, a member of the tumor necrosis factor receptor superfamily (TNFRSF), plays a key role in the activation of the immune system. FAP is abundantly expressed by CAFs in the majority of solid tumors. HSA binding prolongs the half-life of MP0317. Compared to antibodies, DARPins are small in size, have favorable pharmacokinetics and allow for both high affinity binding and efficacy.",
  "synonyms": [
    "FAP x CD40-targeting DARPin MP0317",
    "FAP/CD40-targeting designed ankyrin repeat protein MP0317",
    "anti-CD40/anti-FAP DARPin agent MP0317"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/fap-cd40-targeting-darpin-mp0317/"
}