folate receptor-targeted tubulysin conjugate EC1456

{
  "id": "MLC-T-ONC-013744",
  "term": "folate receptor-targeted tubulysin conjugate EC1456",
  "field": "Oncology and biomedicine",
  "definition": "An injectable targeted small molecule drug conjugate (SMDC) consisting of folate (vitamin B9) covalently linked to the potent mitotic poison and cytotoxic agent, tubulysin B hydrazide (Tub-B-H) with potential antineoplastic activity. Upon administration, the folate moiety of folate receptor-targeted tubulysin conjugate EC1456 preferentially binds to tumor cells expressing folate receptors (FR). After binding to FR, the agent is internalized by tumor cells and the Tub-B-H moiety inhibits the polymerization of tubulin into microtubules. This may lead to both cell cycle arrest and tumor cell apoptosis. FR, the membrane-bound, high-affinity receptor for folate, is overexpressed on a wide range of primary and metastatic human cancers.",
  "synonyms": [
    "folate receptor-targeting folate-tubulysin conjugate EC1456"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/folate-receptor-targeted-tubulysin-conjugate-ec1456/"
}