furosemide/digoxin topical gel CLS003

{
  "id": "MLC-T-ONC-013790",
  "term": "furosemide/digoxin topical gel CLS003",
  "field": "Oncology and biomedicine",
  "definition": "A topical ionic contra-viral therapy (ICVT) gel-based formulation that combines furosemide, a sulfamoylanthranilic acid derivative and loop diuretic, and digoxin, a cardiac glycoside, with potential antiviral activity. Upon topical administration, furosemide interacts with the cell membrane ion co-transporter, Na+-K+-2Cl-co-transporter-1(NKCC1; SLC12A2) and digoxin reversibly inhibits the sodium/potassium-transporting ATPase, leading to a decrease in potassium influx. This may prevent the replication of certain DNA viruses including human papillomavirus (HPV), that rely on potassium for replication.",
  "synonyms": [
    "digoxin-furosemide topical gel CLS003",
    "ICVT product CLS003"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/furosemide-digoxin-topical-gel-cls003/"
}