JAK2 inhibitor BS HH 002.SA

{
  "id": "MLC-T-ONC-014617",
  "term": "JAK2 inhibitor BS HH 002.SA",
  "field": "Oncology and biomedicine",
  "definition": "A derivative of the cytotoxic plant alkaloid homoharringtonine (HHT) and an inhibitor of Janus-associated kinase 2 (JAK2), with potential antineoplastic activity. Upon administration, JAK2 inhibitor BS HH 002.SA inhibits JAK2 activity, thereby preventing the activation of the JAK/signal transducer and activator of transcription (STAT) signaling pathway and the activation of STAT3 and STAT5. This may lead to an induction of tumor cell apoptosis and a decrease in tumor cell proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/jak2-inhibitor-bs-hh-002-sa/"
}