oral Hsp90 inhibitor IPI-493

{
  "id": "MLC-T-ONC-015695",
  "term": "oral Hsp90 inhibitor IPI-493",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable formulation of the ansamycin derivative 17-amino-17-demethoxygeldanamycin (17-AG) with potential antineoplastic activity. Oral Hsp90 inhibitor IPI-493 binds to and inhibits Hsp90, which may result the in growth inhibition in sensitive tumor cell populations. Hsp90, a 90 kDa molecular chaperone, may be highly expressed in tumor cells, playing a key role in the conformational maturation, stability and function of other substrate or \"client\" proteins within the cell; many of these client proteins are involved in signal transduction, cell cycle regulation and apoptosis, and may include kinases, transcription factors and hormone receptors.",
  "synonyms": [
    "heat shock protein 90 inhibitor IPI-493"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/oral-hsp90-inhibitor-ipi-493/"
}