TEAD inhibitor VT3989

{
  "id": "MLC-T-ONC-017006",
  "term": "TEAD inhibitor VT3989",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable, small molecule inhibitor of the auto-palmitoylation of the transcription factor TEAD (TEA domain), with potential antineoplastic activity. Upon oral administration, TEAD inhibitor VT3989 inhibits TEAD auto-palmitoylation, thereby disrupting the interaction between the transcription co-activators yes-associated protein 1 (YAP)/transcriptional coactivator with PDZ-binding motif (TAZ) and TEAD. This may inhibit YAP/TAZ-TEAD promoted gene transcription involved in tumor cell proliferation and survival. The Hippo-YAP/TAZ-TEAD pathway is dysregulated in certain cancers and diseases.",
  "synonyms": [
    "TEAD auto-palmitoylation inhibitor VT3989"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tead-inhibitor-vt3989/"
}