teniposide

{
  "id": "MLC-T-ONC-008587",
  "term": "teniposide",
  "field": "Oncology and biomedicine",
  "definitions": [
    "An anticancer drug that is a podophyllotoxin derivative and belongs to the family of drugs called mitotic inhibitors.",
    "A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle."
  ],
  "abbreviation": "EPT",
  "synonyms": [
    "Thenvlidene-Lignan-P",
    "VM26",
    "Thenylidene-Lignan-P"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/teniposide/"
}