Teprotumumab

{
  "id": "MLC-T-ONC-017067",
  "term": "Teprotumumab",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant, fully human monoclonal antibody directed against the insulin-like growth factor-1 receptor (IGF-1R) with potential antineoplastic activity. Teprotumumab binds to membrane-bound IGF-1R, preventing the binding of the natural ligand IGF-1 and the activation of PI3K/AKT signal transduction; downregulation of the PI3K/AKT survival pathway may result in the induction of apoptosis and decreased cellular proliferation. The activation of IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been implicated in tumorigenesis and metastasis.",
  "synonyms": [
    "immunoglobulin G1, anti-(human insulin-like growth factor I receptor)(human monoclonal heavy chain), disulfide with human monoclonal light chain, dimer",
    "anti-IGF-1 receptor human monoclonal antibody R1507"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/teprotumumab/"
}