therapeutic angiotensin-(1-7)

{
  "id": "MLC-T-ONC-008639",
  "term": "therapeutic angiotensin-(1-7)",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of several types of cancer. Therapeutic angiotensin-(1-7) is a hormone that is made in the laboratory, and helps control blood pressure. It may stop the growth of some types of cancer cells and may stop the growth of blood vessels needed by tumors to grow. It is a type of antiproliferative agent.",
    "A synthetic heptapeptide identical to endogenous angiotensin-(1-7) with vasodilator and antiproliferative activities. Therapeutic angiotensin 1-7 may inhibit cyclooxygenase 2 (COX-2) and the production of proinflammatory prostaglandins and may activate the angiotensin-(1-7) receptor Mas, resulting in diminished tumor cell proliferation. Activation of the angiotensin-(1-7) receptor Mas, a G-protein coupled, seven transmembrane protein, may down-regulate the phophorylation and activation of Erk1 and Erk2 in the Erk1/Erk2 Mapk signaling pathway. In the renin-angiotensin system, the vasodlilating activity of angiotensin- (1-7), hydrolysed from angiotensin II by the type I transmembrane metallopeptidase and carboxypeptidase angiotensin converting enzyme 2 (ACE2) in vivo, counteracts the vasoconstricting activity of angiotensin II."
  ],
  "abbreviation": "therapeutic Ang-(1-7)",
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/therapeutic-angiotensin-1-7/"
}