thiamine

{
  "id": "MLC-T-ONC-008648",
  "term": "thiamine",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Thiamine helps some enzymes work properly, helps break down sugars in the diet, and keeps nerves and the heart healthy. It is found in pork, organ meats, peas, beans, nuts, and whole grains. Thiamine is water-soluble (can dissolve in water) and must be taken in daily. Not enough thiamine can cause a disease called beriberi (a condition marked by heart, nerve, and digestive disorders). Too much thiamine may help cancer cells grow faster. Also called vitamin B1.",
    "A heat-labile and water-soluble essential vitamin, belonging to the vitamin B family, with antioxidant, erythropoietic, mood modulating, and glucose-regulating activities. Thiamine reacts with adenosine triphosphate (ATP) to form an active coenzyme, thiamine pyrophosphate. Thiamine pyrophosphate is necessary for the actions of pyruvate dehydrogenase and alpha-ketoglutarate in carbohydrate metabolism and for the actions of transketolase, an enzyme that plays an important role in the pentose phosphate pathway. Thiamine plays a key role in intracellular glucose metabolism and may inhibit the action of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine may also protect against lead toxicity by inhibiting lead-induced lipid peroxidation."
  ],
  "abbreviation": "vit B1",
  "synonyms": [
    "vitamin B1",
    "B1 vitamin",
    "thiamin",
    "vitamin-B1",
    "aneurin"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/thiamine/"
}