thioredoxin-1 inhibitor PX-12

{
  "id": "MLC-T-ONC-017142",
  "term": "thioredoxin-1 inhibitor PX-12",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable small molecule with potential antineoplastic activity. Thioredoxin-1 inhibitor PX-12 irreversibly binds to thioredoxin-1 (Trx-1) and inhibits its activity, which may result in growth inhibition and the induction of apoptosis. Overexpressed in many cancer cell types, the low molecular weight redox protein Trx-1 regulates transcription factor activity and inhibits apoptosis, promoting cell growth and survival; it also interacts with growth factors extracellularly to stimulate cell growth.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/thioredoxin-1-inhibitor-px-12/"
}