Tirabrutinib

{
  "id": "MLC-T-ONC-017182",
  "term": "Tirabrutinib",
  "field": "Oncology and biomedicine",
  "definition": "An orally available formulation containing an inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, tirabrutinib covalently binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development. As a result, this agent may inhibit the proliferation of B-cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.",
  "synonyms": [
    "BTK inhibitor ONO-4059",
    "Bruton's tyrosine kinase inhibitor ONO-4059"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tirabrutinib/"
}