Tolcapone

{
  "id": "MLC-T-ONC-017227",
  "term": "Tolcapone",
  "field": "Oncology and biomedicine",
  "definition": "A benzophenone derivative and a catechol-O-methyltransferase (COMT) inhibitor. Tolcapone selectively and reversibly inhibits COMT, an enzyme that catalyzes the metabolism of biologically active catechols and their hydroxylated metabolites by transferring the methyl group of S-adenosyl-L-methionine to the phenolic group of catechol-containing substrates. When given in conjunction with a peripheral dopa decarboxylase inhibitor and levodopa, tolcapone may prevent the metabolism of levodopa to 3-methoxy-4-hydroxy- L-phenylalanine (3-OMD) in the brain and peripheral tissues leading to increased bioavailability and enhancement of delivery to the central nervous system (CNS) of levodopa.",
  "synonyms": [
    "Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-",
    "3,4-dihydroxy-4'-methyl-5-nitrobenzophenone"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tolcapone/"
}