trastuzumab

{
  "id": "MLC-T-ONC-008872",
  "term": "trastuzumab",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used alone or with other drugs to treat certain types of breast cancer, stomach cancer, and gastroesophageal junction cancer that are HER2 positive. It is also being studied in the treatment of other types of cancer. Trastuzumab binds to a protein called HER2, which is found on some cancer cells. This may help the immune system kill cancer cells. Trastuzumab is a type of monoclonal antibody and a type of HER2 receptor antagonist. Also called Herceptin, Hercessi, Herzuma, Kanjinti, Ogivri, Ontruzant, and Trazimera.",
    "A recombinant humanized monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2). After binding to HER2 on the tumor cell surface, trastuzumab induces an antibody-dependent cell-mediated cytotoxicity against tumor cells that overexpress HER2. HER2 is overexpressed by many adenocarcinomas, particularly breast adenocarcinomas."
  ],
  "abbreviation": "MoAB HER2",
  "synonyms": [
    "Herceptin",
    "Hercessi",
    "Herzuma",
    "Kanjinti",
    "Ogivri",
    "Ontruzant",
    "Trazimera",
    "trastuzumab-strf",
    "trastuzumab biosimilar QL1701",
    "trastuzumab-anns",
    "trastuzumab-dttb",
    "trastuzumab-qyyp",
    "anti-c-erB-2",
    "anti-c-erbB2 monoclonal antibody",
    "anti-ERB-2",
    "anti-erbB-2",
    "anti-erbB2 monoclonal antibody",
    "anti-HER2/c-erbB2 monoclonal antibody",
    "anti-p185-HER2",
    "Herceptin biosimilar PF-05280014",
    "trastuzumab biosimilar PF-05280014",
    "MoAB HER2",
    "monoclonal antibody HER2",
    "monoclonal antibody c-erb-2",
    "trastuzumab biosimilar SIBP-01",
    "trastuzumab biosimilar ABP 980",
    "trastuzumab biosimilar SB3",
    "trastuzumab biosimilar HLX02",
    "trastuzumab biosimilar ALT02",
    "trastuzumab biosimilar EG12014",
    "c-erb-2 monoclonal antibody",
    "Herceptin trastuzumab biosimilar PF-05280014",
    "trastuzumab-dkst",
    "trastuzumab-pkrb",
    "trastuzumab biosimilar CT-P6"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/trastuzumab/"
}