Triciribine phosphate

{
  "id": "MLC-T-ONC-017319",
  "term": "Triciribine phosphate",
  "field": "Oncology and biomedicine",
  "definition": "The phosphate salt of the synthetic, cell-permeable tricyclic nucleoside triciribine with potential antineoplastic activity. Triciribine inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3, which may result in the inhibition of Akt-expressing tumor cell proliferation. Akts are anti-apoptotic serine/theronine-specific protein kinases that phosphorylate and inactivate components of the apoptotic machinery, including Bcl-xL/Bcl-2-associated death promoter (BAD) and caspase 9.",
  "abbreviation": "TCN-P",
  "synonyms": [
    "tricyclic nucleoside 5'-phosphate",
    "tricycloside phosphate"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/triciribine-phosphate/"
}