vascular endothelial growth factor-antisense oligonucleotide

{
  "id": "MLC-T-ONC-009180",
  "term": "vascular endothelial growth factor-antisense oligonucleotide",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance that has been studied in the treatment of cancer. It binds to the RNA for a protein called vascular endothelial growth factor (VEGF) that stimulates the growth of new blood vessels. Vascular endothelial growth factor-antisense oligonucleotide blocks the cell’s ability to make VEGF, which may kill tumors that need new blood vessels to grow. It is a type of antisense oligonucleotide and a type of gene expression inhibitor. Also called VEGF-AS.",
    "An antisense oligonucleotide with potential antiangiogenesis activity. Vascular endothelial growth factor (VEGF) antisense oligonucleotide binds directly to binds VEGF A/C/D mRNA, leading to mRNA degradation and the inhibition of VEGF A-mediated angiogenesis and VEGF C/D-mediated lymphangiogenesis."
  ],
  "abbreviation": "VEGF-AS",
  "synonyms": [
    "VEGF-AS",
    "VEGF antisense oligonucleotide"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/vascular-endothelial-growth-factor-antisense-oligonucleotide/"
}