Vitamin D3 analogue ILX23-7553

{
  "id": "MLC-T-ONC-017516",
  "term": "Vitamin D3 analogue ILX23-7553",
  "field": "Oncology and biomedicine",
  "definition": "A vitamin D3 analogue with potential antineoplastic activity. ILX23-7553 binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor, this agent induces cancer cell differentiation, inhibits cancer cell growth and induces apoptosis. In addition, ILX23-7553 may also induce growth arrest and apoptosis independent of vitamin D receptor activation through mechanisms that are not fully elucidated.",
  "synonyms": [
    "16-23-D3"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/vitamin-d3-analogue-ilx23-7553/"
}