Vitamin K1-containing urea skin cream

{
  "id": "MLC-T-ONC-017518",
  "term": "Vitamin K1-containing urea skin cream",
  "field": "Oncology and biomedicine",
  "definition": "A topical cream containing urea and 0.1% vitamin K1 (phytomenadione) with topical epidermal growth factor receptor (EGFR)-activating activity. Upon application of vitamin K1-containing urea skin cream, vitamin K1 may locally activate EGFR, thereby abrogating EGFR inhibition in the skin caused by systemic EGFR inhibiting agents. This may help inhibit the acne-like skin rash induced by EGFR antagonists. EGFR, a tyrosine kinase, plays a key role in maintaining epidermal integrity.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/vitamin-k1-containing-urea-skin-cream/"
}