W_pro1 cancer vaccine

{
  "id": "MLC-T-ONC-017569",
  "term": "W_pro1 cancer vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A messenger ribonucleic acid (mRNA)-based cancer vaccine that encodes five prostate cancer-selective off-the-shelf shared antigens that are separately complexed with liposomes to form serum-stable RNA lipoplexes (RNA-LPX), with potential immunomodulating and antineoplastic activities. Upon intravenous administration of the W_pro1 cancer vaccine, the RNA-LPX are taken up by antigen-presenting cells (APCs), especially dendritic cells (DCs). Upon uptake, the antigens are translated, processed, and presented to the immune system on major histocompatibility complex (MHC) class I and II molecules. This may activate the immune system to induce both an adaptive and innate immune response against cancer cells expressing these five antigens.",
  "synonyms": [
    "RNA-lipoplex cancer vaccine BNT112",
    "RNA-lipoplex vaccine BNT112",
    "RNA-LPX BNT112",
    "WP1 cancer vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/w-pro1-cancer-vaccine/"
}