xentuzumab

{
  "id": "MLC-T-ONC-017596",
  "term": "xentuzumab",
  "field": "Oncology and biomedicine",
  "definition": "A humanized IgG1 insulin-like growth factor (IGF) monoclonal antibody targeting the IGF ligands 1 (IGF-1) and 2 (IGF-2), with potential antineoplastic activity. Upon administration, xentuzumab binds to both IGF-1 and IGF-2 and inhibits the binding of these ligands to their receptor, IGF-1R. This blocks the insulin growth factor (IGF) signaling pathway, which is upregulated in a number of cancer cell types and plays a key role in cancer cell proliferation and chemoresistance. In addition, xentuzumab prevents the binding of IGF-2 to insulin receptor variant A (IR-A), preventing its activation.",
  "synonyms": [
    "IGF ligand neutralizing antibody BI 836845"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/xentuzumab/"
}